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operational model plus agonism graphpad prism 8.02  (GraphPad Software Inc)
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GraphPad Software Inc operational model plus agonism graphpad prism 8.02
Multi-pathway profiling at the A 2A R, A 2B R and A 3 R. Adenosine receptor <t>agonism</t> was analyzed in CHO-hA 2A R (left panels), CHO-hA 2B R (center panels) and CHO-hA 3 R cells (right panels) . Cells were analyzed in cAMP (top row) , calcium (second row) , and phosphorylation of ERK1/2 (third row) and Akt1/2/3 (fourth row) , with calculated bias shown in the lower row. As bias data are normalized to NECA and the cAMP pathway, where there is no response to NECA at a pathway, ligand-induced cAMP in a cell line, bias cannot be calculated. Statistical analyses of bias are shown in . Concentration response data are expressed as mean ± SEM.
Operational Model Plus Agonism Graphpad Prism 8.02, supplied by GraphPad Software Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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operational model plus agonism graphpad prism 8.02 - by Bioz Stars, 2026-04
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Multi-pathway profiling at the A 2A R, A 2B R and A 3 R. Adenosine receptor agonism was analyzed in CHO-hA 2A R (left panels), CHO-hA 2B R (center panels) and CHO-hA 3 R cells (right panels) . Cells were analyzed in cAMP (top row) , calcium (second row) , and phosphorylation of ERK1/2 (third row) and Akt1/2/3 (fourth row) , with calculated bias shown in the lower row. As bias data are normalized to NECA and the cAMP pathway, where there is no response to NECA at a pathway, ligand-induced cAMP in a cell line, bias cannot be calculated. Statistical analyses of bias are shown in . Concentration response data are expressed as mean ± SEM.

Journal: Frontiers in Pharmacology

Article Title: Pharmacological Insights Into Safety and Efficacy Determinants for the Development of Adenosine Receptor Biased Agonists in the Treatment of Heart Failure

doi: 10.3389/fphar.2021.628060

Figure Lengend Snippet: Multi-pathway profiling at the A 2A R, A 2B R and A 3 R. Adenosine receptor agonism was analyzed in CHO-hA 2A R (left panels), CHO-hA 2B R (center panels) and CHO-hA 3 R cells (right panels) . Cells were analyzed in cAMP (top row) , calcium (second row) , and phosphorylation of ERK1/2 (third row) and Akt1/2/3 (fourth row) , with calculated bias shown in the lower row. As bias data are normalized to NECA and the cAMP pathway, where there is no response to NECA at a pathway, ligand-induced cAMP in a cell line, bias cannot be calculated. Statistical analyses of bias are shown in . Concentration response data are expressed as mean ± SEM.

Article Snippet: For concentration response data, curves were analyzed using three-parameter nonlinear curve fitting (GraphPad Prism 8.02) of grouped data. pK b values of VCP746 at hA 3 receptor were determined using the Schild method ( ) and calculated using the operational model plus agonism (GraphPad Prism 8.02).

Techniques: Phospho-proteomics, Concentration Assay